Intraoperative ventilation with air and oxygen during laparoscopic cholecystectomy decreases the degree of postoperative hypoxaemia
Abstract
We studied the effects of intraoperative use of air in oxygen (O2) (FiO2 =0.33) versus nitrous oxide (N2O) in O2 (FiO2 =0.33) on the degree of postoperative hypoxaemia in 30 patients undergoing laparoscopic cholecystectomy. Patients were randomly allocated to receive either general anaesthesia with air (Group A, n =15) or with N2O (Group N, n =15). Arterial gas tensions were measured before, 24h and 48h after surgery while breathing room air. The mean PaO2 24h and 48h postoperatively decreased significantly in both groups compared with the preoperative values. The mean PaO2 24h postoperatively in Group N (74.6 ± 6.4 mmHg) tended to be lower than that in Group A (78.1 ± 8.3 mmHg). The mean PaO2 48h postoperatively in Group N (75.0 ± 7.8 mmHg) was significantly lower than that in Group A (83.5 ± 7.9 mmHg) (P <0.05). On the contrary, the mean PaCO2 did not show any significant change during 48h postoperatively in either group. Our results suggest that ventilation with N2O and O2 during laparoscopic cholecystectomy is associated with a lower degree of postoperative hypoxaemia.
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